Tg(MMTV-NCOA3)#Mybr
Transgene Detail

Summary

• Symbol: Tg(MMTV-NCOA3)#Mybr
• Name: transgene insertion, Myles Brown
• MGI ID: MGI:5762986
• Synonyms: AIB1-tg
• Transgene: Tg(MMTV-NCOA3)#Mybr Location: unknown
• Alliance: Tg(MMTV-NCOA3)#Mybr page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-NCOA3)#Mybr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NCOA3 (8202)

  Ncoa3

  (MGI:1276535)

• Mutation details: A 4.8 kb fragment of human NCOA3 cDNA is under the control of the mouse mammary tumor virus long terminal repeat promoter/enhancer. Seven lines (D3, D4, D5, D6, H3-1, H3-12, and H3-2) were generated, however the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:93548)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-NCOA3)#Mybr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:93548 Torres-Arzayus MI, et al., High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene. Cancer Cell. 2004 Sep;6(3):263-74
• All: 2 reference(s)