Kat6a^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Kat6a^{tm1c(EUCOMM)Wtsi}
• Name: K(lysine) acetyltransferase 6A; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5763051
• Synonyms: Moz^f
• Gene: Kat6a Location: Chr8:23349551-23433275 bp, + strand Genetic Position: Chr8, 11.42 cM
• Alliance: Kat6a^{tm1c(EUCOMM)Wtsi} page
• IMPC: Kat6a gene page

Mutation origin

• Mutant Cell Line: EPD0028_5_E11
• Germline Transmission: Earliest citation of germline transmission: J:224155
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_gt0
• Mutation details: The L1L2_gt0 cassette was inserted at position 23392698 of Chromosome 8 upstream of the critical exon 4 (the second coding exon) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon 4 (the second coding exon) at position 23393492. The critical exon 4 (the second coding exon) is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:224155)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kat6a Mutation: 69 strains or lines available

Notes

Cell line EPD0028_5_E11 was successfully used to make chimeric mice. Germline transmission was accomplished. J:224155

References

• Original: J:224155 You L, et al., The lysine acetyltransferase activator Brpf1 governs dentate gyrus development through neural stem cells and progenitors. PLoS Genet. 2015 Mar;11(3):e1005034
• All: 1 reference(s)