Supt4a^tm1Yty
Targeted Allele Detail

Summary

• Symbol: Supt4a^tm1Yty
• Name: SPT4A, DSIF elongation factor subunit; targeted mutation 1, Yu-Ting Yan
• MGI ID: MGI:5763055
• Gene: Supt4a Location: Chr11:87628378-87634449 bp, + strand Genetic Position: Chr11, 52.2 cM
• Alliance: Supt4a^tm1Yty page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224237
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced exons 2 through 5. RT-PCR confirmed a 50% reduction in transcript expression in cerebral tissue of heterozygotes. (J:224237)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Supt4a Mutation: 17 strains or lines available

References

• Original: J:224237 Cheng HM, et al., Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown. PLoS Genet. 2015 Mar;11(3):e1005043
• All: 1 reference(s)