Ank2^tm2Bnt
Targeted Allele Detail

Summary

• Symbol: Ank2^tm2Bnt
• Name: ankyrin 2, brain; ankyrin 2, brain; targeted mutation 2, Vann Bennett
• MGI ID: MGI:5763064
• Synonyms: Ank2^L1622I
• Gene: Ank2 Location: Chr3:126715261-127292999 bp, - strand Genetic Position: Chr3, 56.07 cM
• Alliance: Ank2^tm2Bnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222913
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Insertion
• Mutation details: An L1622I (CTG to ATC) mutation in exon 19 and loxP-flanked neomycin cassette were knocked into the gene. In humans, the mutation is involved with the setting of hereditary cardiac arrhythmia. (J:222913)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ank2 Mutation: 185 strains or lines available

References

• Original: J:222913 Lorenzo DN, et al., Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic beta cell insufficiency. J Clin Invest. 2015 Aug 3;125(8):3087-3102
• All: 1 reference(s)