Crkltm1.1Bem
Targeted Allele Detail
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Symbol: |
Crkltm1.1Bem |
Name: |
v-crk avian sarcoma virus CT10 oncogene homolog-like; targeted mutation 1.1, Bernice Morrow |
MGI ID: |
MGI:5763398 |
Synonyms: |
Crkl-null |
Gene: |
Crkl Location: Chr16:17269851-17305298 bp, + strand Genetic Position: Chr16, 10.82 cM
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Alliance: |
Crkltm1.1Bem page
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Germline Transmission: |
Earliest citation of germline transmission:
J:230261
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 1. A floxed neomycin resistance cassette was inserted downstream of exon 1. Cre-mediated recombination removed exon 1 and a selection cassette. RT-PCR confirmed the absence of protein expression in E10.5 hearts.
(J:230261)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Crkl Mutation: |
17 strains or lines available
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Original: |
J:230261 Racedo SE, et al., Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation. Am J Hum Genet. 2015 Feb 5;96(2):235-44 |
All: |
2 reference(s) |
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