Oaz2^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Oaz2^em1(IMPC)J
• Name: ornithine decarboxylase antizyme 2; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:5763465
• Synonyms: Oaz2^em1J
• Gene: Oaz2 Location: Chr9:65583830-65597582 bp, + strand Genetic Position: Chr9, 35.45 cM
• Alliance: Oaz2^em1(IMPC)J page
• IMPC: Oaz2 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele from project Oaz2-7565J-M3140 was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences CTGCCCTGAGAATGGCCCAA, TCCTATGCTCCCTAAACCAA, TGGGAATCTGATAAACTGGT and CAAAACATCTACTAACTCAG, which resulted in a 463 bp deletion spanning exon 4 beginning at Chromosome 9 positive strand position 65,687,700 bp, CTGAGAATGGCCCAAGGGAT, and ending after CCACCAGTTTATCAGATTCC at 65688162 bp (GRCm38/mm10). This mutation deletes exon 4 and 287 bp of flanking intronic sequence including the splice acceptor and donor, and is predicted to cause a change of amino acid sequence after residue 59 and early truncation 8 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oaz2 Mutation: 49 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)