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Serpine1tm1.1Vlp
Targeted Allele Detail
Summary
Symbol: Serpine1tm1.1Vlp
Name: serine (or cysteine) peptidase inhibitor, clade E, member 1; targeted mutation 1.1, Victoria A Ploplis
MGI ID: MGI:5763484
Synonyms: PAI-1R101A/Q123K
Gene: Serpine1  Location: Chr5:137090358-137101122 bp, - strand  Genetic Position: Chr5, 76.16 cM
Alliance: Serpine1tm1.1Vlp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:230643
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6 x 129
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 3 was replaced with a modified one in which nucleotide substitutions result in the amino acid substitutions of alanine for arginine at position 101 (R101A) and lysine for glutamine at position 123 (Q123K). Flp-mediated recombination removed the FRT- and loxP-flanked neomycin resistance cassette inserted downstream of the modified exon 3. (J:230643)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Serpine1 Mutation:  25 strains or lines available
References
Original:  J:230643 Narasaki R, et al., The vitronectin-binding domain of plasminogen activator inhibitor-1 plays an important functional role in lipopolysaccharide-induced lethality in mice. J Thromb Haemost. 2012 Dec;10(12):2618-21
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory