Mrps34^m1Anu
Chemically induced Allele Detail

Summary

• Symbol: Mrps34^m1Anu
• Name: mitochondrial ribosomal protein S34; mutation 1, Australian National University
• MGI ID: MGI:5763565
• Synonyms: ENU19:B6:MRPS34, Mrps34^m1Apb, Mrps34^mut
• Gene: Mrps34 Location: Chr17:25114094-25115263 bp, + strand Genetic Position: Chr17, 12.53 cM
• Alliance: Mrps34^m1Anu page

Mutation origin

• Strain of Origin: C57BL/6JAnu

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C point mutation that results in the amino acid substitution of proline for leucine at position 68 (L668P). Western blot analysis confirmed the absence of protein expression in the heart and liver. (J:222643)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mrps34 Mutation: 9 strains or lines available

References

• Original: J:222643 Richman TR, et al., Mutation in MRPS34 compromises protein synthesis and causes mitochondrial dysfunction. PLoS Genet. 2015 Mar;11(3):e1005089
• All: 2 reference(s)