Tpnr6^A/J
QTL Variant Detail

Summary

• QTL variant: Tpnr6^A/J
• Name: thermal pain response 6; A/J
• MGI ID: MGI:5763819
• QTL: Tpnr6 Location: Chr8:111166632-114956740 bp Genetic Position: Chr8, Syntenic

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:215970

QTL Reference Notes

The Diversity Outbred heterogeneous stock (J:DO) is a developing mouse population derived from progenitor lines of the Collaborative Cross (CC). The CC is a panel of recombinant inbred (RI) mouse strains that combines the genomes of eight genetically diverse founder strains - A/J, C57BL/6J, 129S1/SvImJ, NOD/ShiLtJ, NZO/HlLtJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ - to capture nearly 90% of the known variation present in laboratory mice (Churchill et al. 2004). Animals from 160 incipient CC lines at early stages of inbreeding were used to establish the DO population, which is maintained by a randomized outbreeding strategy that avoids brother-sister matings. The DO and CC populations thus capture the same set of natural allelic variants derived from a common set of eight founder strains, with DO mice being outbred and the CC population being inbred. CTC (2004), Churchill, G. A., et al.. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 36, 1133-7.

Linkage analysis was performed on 261 male and female J:DO mice (from generations G4 and G5) using 7,851 SNP markers to identify QTL associated with acute thermal pain sensitivity (hot plate test). All coordinates are relative to GRCm38.

QTL Tpnr6 maps to 110.44 - 114.23 Mb (UNC080383989 - rs31329971) on Chromosome 8 with a peak LOD score of 6.1 at 113.02 Mb (rs31242180) in linkage with hot plate sensitivity. A/J alleles confer increased susceptibility to acute thermal pain; C57BL/6J alleles confer decreased susceptibility to acute thermal pain. The protein-coding gene Hydin is reported as a candidate gene.

References

• Original: J:215970 Recla JM, et al., Precise genetic mapping and integrative bioinformatics in Diversity Outbred mice reveals Hydin as a novel pain gene. Mamm Genome. 2014 Jun;25(5-6):211-22
• All: 1 reference(s)