Frmpd1^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Frmpd1^em1(IMPC)J
• Name: FERM and PDZ domain containing 1; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:5766262
• Synonyms: Frmpd1^em1J
• Gene: Frmpd1 Location: Chr4:45184875-45285936 bp, + strand Genetic Position: Chr4, 23.77 cM
• Alliance: Frmpd1^em1(IMPC)J page
• IMPC: Frmpd1 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele from project Frmpd1-7623J-M1181 was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences GGTCAGCCCAAGGATAACAG, ATACACAGAATTTCAAAAGG, GCCCAGCTACTCTCCCTAAG and TGCCTTTTTTACAGGTCAGG, which resulted in a 301 bp deletion spanning exon 3 beginning at Chromosome 4 positive strand position 45243539 bp, CTTTCCTCTGTTATCCTTGGG, and ending after TAGCCTCTTAGGGAGAGTAG at 45243839 bp (GRCm38/mm10). This mutation deletes exon 3 and 143 bp of flanking intronic sequence including the splice acceptor and donor, and is predicted to cause a change of amino acid sequence after residue 34 and early truncation 10 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Frmpd1 Mutation: 63 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)