Plcz1^em2Jparr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Plcz1^em2Jparr
• Name: phospholipase C, zeta 1; endonuclease-mediated mutation 2, John Parrington
• MGI ID: MGI:5766360
• Gene: Plcz1 Location: Chr6:139935399-139987183 bp, - strand Genetic Position: Chr6, 69.77 cM, cytoband G1
• Alliance: Plcz1^em2Jparr page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using one sgRNA and CRISPR/Cas9 technology, 17 nucleotides (TCAAATATTGGGACCGA in NM_054066) were deleted from exon 5. Any potential C-terminally truncated peptide expressed from this allele would lack most functional domains. (J:243414)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcz1 Mutation: 56 strains or lines available

References

• Original: J:243414 Hachem A, et al., PLCzeta is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence. Development. 2017 Aug 15;144(16):2914-2924
• All: 1 reference(s)