Altc1^NOD/ShiLtJ
QTL Variant Detail

Summary

• QTL variant: Altc1^NOD/ShiLtJ
• Name: ALT fold changes 1, EGCG induced; NOD/ShiLtJ
• MGI ID: MGI:5766374
• QTL: Altc1 Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: NOD/ShiLtJ

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:229083

QTL Reference Notes

The Diversity Outbred heterogeneous stock (J:DO) is a developing mouse population derived from progenitor lines of the Collaborative Cross (CC). The CC is a panel of recombinant inbred (RI) mouse strains that combines the genomes of eight genetically diverse founder strains - A/J, C57BL/6J, 129S1/SvImJ, NOD/ShiLtJ, NZO/HlLtJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ - to capture nearly 90% of the known variation present in laboratory mice (Churchill et al. 2004). Animals from 160 incipient CC lines at early stages of inbreeding were used to establish the DO population, which is maintained by a randomized outbreeding strategy that avoids brother-sister matings. The DO and CC populations thus capture the same set of natural allelic variants derived from a common set of eight founder strains, with DO mice being outbred and the CC population being inbred. CTC (2004), Churchill, G. A., et al.. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 36, 1133-7.

Linkage analysis was performed on a mapping population of male J:DO mice (G7-8) to identify loci related to EGCG-induced hepatotoxicity (ALT fold changes). SNP genotyping was performed utilizing the Mouse Universal Genotyping Array, an Illumina Infinium Platform array with 7851 evenly spaced SNP markers. All coordinates are relative to NCBI GRCm37 (mm9).

QTL Altc1 (ALT fold change 1) maps to 142.59 - 151.78 Mb on Chromosome 4 with a peak LOD score of 5.94. Alleles inherited from the NOD/ShiLtJ founder strain are reported to confer resistance to EGCG-induced hepatotoxicity.

References

• Original: J:229083 Church RJ, et al., Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice. Food Chem Toxicol. 2015 Feb;76:19-26
• All: 1 reference(s)