Tg(tetO-NPM1/ALK,-luc)2Gde
Transgene Detail

Summary

• Symbol: Tg(tetO-NPM1/ALK,-luc)2Gde
• Name: transgene insertion 2, Georges Delsol
• MGI ID: MGI:5766488
• Synonyms: pBIL-NA
• Transgene: Tg(tetO-NPM1/ALK,-luc)2Gde Location: unknown
• Alliance: Tg(tetO-NPM1/ALK,-luc)2Gde page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-NPM1/ALK,-luc)2Gde expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ALK (238)

  Alk	(MGI:103305)

  human

  NPM1 (4869)

  Npm1	(MGI:106184)

• Mutation details: The tetracycline-responsive element with a bidirectional CMV minimal promoter drives inducible expression of a cDNA encoding the human tumor-associated NPM1/ALK fusion protein and a firefly luciferase gene. Three lines (1, 2, and 3) were generated. (J:160236)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:160236 Giuriato S, et al., Conditional TPM3-ALK and NPM-ALK transgenic mice develop reversible ALK-positive early B-cell lymphoma/leukemia. Blood. 2010 May 20;115(20):4061-70
• All: 2 reference(s)