Slc24a1^tm1Xen
Targeted Allele Detail

Summary

• Symbol: Slc24a1^tm1Xen
• Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 1; targeted mutation 1, Taconic Biosciences
• MGI ID: MGI:5766542
• Synonyms: Nckx1^-
• Gene: Slc24a1 Location: Chr9:64830143-64858889 bp, - strand Genetic Position: Chr9, 35.0 cM
• Alliance: Slc24a1^tm1Xen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226323
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of the second exon was deleted and replaced by a LacZ/neomycin cassette via homologous recombination. Western blot confirmed absence of protein in retinal extracts. (J:226323)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc24a1 Mutation: 32 strains or lines available

References

• Original: J:226323 Vinberg F, et al., A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease. Hum Mol Genet. 2015 Oct 15;24(20):5915-29
• All: 3 reference(s)