Zc3hav1^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Zc3hav1^tm1Aki
• Name: zinc finger CCCH type, antiviral 1; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:5767101
• Gene: Zc3hav1 Location: Chr6:38282221-38331538 bp, - strand Genetic Position: Chr6, 17.72 cM, cytoband B1
• Alliance: Zc3hav1^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198791
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Most of exon 1 was replaced with a neomycin resistance cassette. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:198791)

Generation of the Zc3hav1^tm1Aki allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zc3hav1 Mutation: 45 strains or lines available

References

• Original: J:198791 Lee H, et al., Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12379-84
• All: 2 reference(s)