Mad2l2^tm1Mpz
Targeted Allele Detail

Summary

• Symbol: Mad2l2^tm1Mpz
• Name: MAD2 mitotic arrest deficient-like 2; targeted mutation 1, Mehdi Pirouz
• MGI ID: MGI:5769977
• Synonyms: Mad2l2^lox
• Gene: Mad2l2 Location: Chr4:148214841-148230156 bp, + strand Genetic Position: Chr4, 78.67 cM, cytoband E1
• Alliance: Mad2l2^tm1Mpz page

Intrinsic failure of Mad2l2^tm1Mpz/Mad2l2^tm1Mpz Tg(Prdm1-cre)1Masu/0 primordial germ cells

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223048
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 8. (J:223048)

Generation of the Mad2l2^tm1Mpz and Mad2l2^tm1.1Mpz aleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mad2l2 Mutation: 15 strains or lines available

References

• Original: J:223048 Pirouz M, et al., A critical function of Mad2l2 in primordial germ cell development of mice. PLoS Genet. 2013 Aug;9(8):e1003712
• All: 1 reference(s)