Akt1s1^tm1.1Rrth
Targeted Allele Detail

Summary

• Symbol: Akt1s1^tm1.1Rrth
• Name: AKT1 substrate 1; targeted mutation 1.1, Richard Roth
• MGI ID: MGI:5769980
• Gene: Akt1s1 Location: Chr7:44498648-44504845 bp, + strand Genetic Position: Chr7, 28.94 cM, cytoband B2
• Alliance: Akt1s1^tm1.1Rrth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231219
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted between exons 1 and 2 and after exon 5. An FRT-flanked neomycin resistance cassette was used for selection. Cre-mediated recombination removed exons 2 through 5, the entire coding region. (J:231219)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akt1s1 Mutation: 44 strains or lines available

References

• Original: J:231219 Xiong X, et al., PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways. Neurobiol Dis. 2014 Jun;66:43-52
• All: 2 reference(s)