Vps33b^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Vps33b^tm1.1Arte
• Name: vacuolar protein sorting 33B; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5770088
• Synonyms: Vps33b^fl
• Gene: Vps33b Location: Chr7:79919369-79941323 bp, + strand Genetic Position: Chr7, 45.59 cM
• Alliance: Vps33b^tm1.1Arte page

Abnormal collagen structure in Vipas39^{tm1c(KOMP)Mbp}/Vipas39^{tm1c(KOMP)Mbp} Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺, and Vps33b^tm1.1Arte/Vps33b^tm1.1Arte Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ mouse tail tendon

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222766
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2 and 3 were floxed. The final allele lacks a selection cassette, leaving an FRT site upstream of exon 2. (J:222766)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vps33b Mutation: 30 strains or lines available

References

• Original: J:222766 Bem D, et al., VPS33B regulates protein sorting into and maturation of alpha-granule progenitor organelles in mouse megakaryocytes. Blood. 2015 Jul 9;126(2):133-43
• All: 6 reference(s)