Del(7Ffar2-Ffar3)1Soff
Targeted Allele Detail

Summary

• Symbol: Del(7Ffar2-Ffar3)1Soff
• Name: deletion, Chr 7, Stefan Offermanns 1
• MGI ID: MGI:5770474
• Synonyms: Del1Soff, Ffar2^-/Ffar3^-
• Gene: Del(7Ffar2-Ffar3)1Soff Location: unknown Genetic Position: Chr7, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227939
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(7Ffar2-Ffar3)1Soff involves 3 genes/genome features (Ffar2, Gm32236, Ffar3) View all
• Mutation details: Cre-mediated recombination between Ffar2^tm2Soff and Ffar3^tm2.1Soff results in deletion of both coding regions and the sequence between. (J:227939)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(7Ffar2-Ffar3)1Soff Mutation: 0 strains or lines available

References

• Original: J:227939 Tang C, et al., Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes. Nat Med. 2015 Feb;21(2):173-7
• All: 3 reference(s)