Marcks^tm2.1Pjb
Targeted Allele Detail

Summary

• Symbol: Marcks^tm2.1Pjb
• Name: myristoylated alanine rich protein kinase C substrate; targeted mutation 2.1,Perry J Blackshear
• MGI ID: MGI:5770609
• Synonyms: MARCKS^F
• Gene: Marcks Location: Chr10:37009371-37014916 bp, - strand Genetic Position: Chr10, 19.49 cM
• Alliance: Marcks^tm2.1Pjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227580
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neomycin resistance cassette was inserted downstream of exon 2. Cre-mediated recombination removed the selection cassette and left exon 2 floxed. (J:227580)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Marcks Mutation: 13 strains or lines available

References

• Original: J:227580 Muthusamy N, et al., MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging. Aging Cell. 2015 Oct;14(5):764-73
• All: 2 reference(s)