Sufu^rgsc2062
Chemically induced Allele Detail

Summary

• Symbol: Sufu^rgsc2062
• Name: SUFU negative regulator of hedgehog signaling; RIKEN Genomic Sciences Center, 2062
• MGI ID: MGI:5770710
• Synonyms: Sufu^rgsc02062, Sufu^T396I
• Gene: Sufu Location: Chr19:46385335-46477243 bp, + strand Genetic Position: Chr19, 38.85 cM
• Alliance: Sufu^rgsc2062 page

Mutation origin

• Strain of Origin: C57BL/6JJcl

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a C to T point mutation that results in the amino acid substitution of isoleucine for threonine at position 396 (T396I). (J:228335)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sufu Mutation: 59 strains or lines available

References

• Original: J:228335 Makino S, et al., T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor. PLoS One. 2015;10(3):e0119455
• All: 1 reference(s)