Smo^rgsc2073
Chemically induced Allele Detail

Summary

• Symbol: Smo^rgsc2073
• Name: smoothened, frizzled class receptor; RIKEN Genomic Sciences Center, 2073
• MGI ID: MGI:5770717
• Synonyms: Smo^G457X, Smo^rgsc02073
• Gene: Smo Location: Chr6:29735502-29761364 bp, + strand Genetic Position: Chr6, 12.36 cM, cytoband A3.3
• Alliance: Smo^rgsc2073 page

Mutation origin

• Strain of Origin: C57BL/6JJcl

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to A point mutation in exon 7 that results in premature termination at codon 57 (G457X). (J:228335)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Smo Mutation: 39 strains or lines available

References

• Original: J:228335 Makino S, et al., T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor. PLoS One. 2015;10(3):e0119455
• All: 1 reference(s)