Mc1r^tm1.1Mymi
Targeted Allele Detail

Summary

• Symbol: Mc1r^tm1.1Mymi
• Name: melanocortin 1 receptor; targeted mutation 1.1, Mayumi Ito
• MGI ID: MGI:5770883
• Synonyms: Mc1R^fl
• Gene: Mc1r Location: Chr8:124133846-124137483 bp, + strand Genetic Position: Chr8, 72.1 cM
• Alliance: Mc1r^tm1.1Mymi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231435
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a single loxP site upstream of exon 1, and a loxP-flanked and FRT-flanked neomycin resistance (neo) cassette downstream of exon 1. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:231435)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mc1r Mutation: 44 strains or lines available

References

• Original: J:231435 Takeo M, et al., EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling. Cell Rep. 2016 May 10;15(6):1291-302
• All: 2 reference(s)