Col4a1m1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Col4a1m1^C57BL/6J
• Name: collagen, type IV, alpha 1 modifier 1; C57BL/6J
• MGI ID: MGI:5771910
• QTL: Col4a1m1 Location: Chr1:25550191-62946882 bp Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:130287

In an attempt to determin if the Col4a1 mutant phenotypes could be genetically modified the authors crossed mice that were congenic for Col4a1 on a C57BL/6J genetic background to mice of inbred strains (129/SvEvTac and CAST/EiJ). The F1 mice derived fromthis cross were analysed. A single dominate locus between D1Mit211 and D1Mit303 was shown in CAST/EiJ mice.

References

• Original: J:130287 Gould DB, et al., Col4a1 mutation causes endoplasmic reticulum stress and genetically modifiable ocular dysgenesis. Hum Mol Genet. 2007 Apr 1;16(7):798-807
• All: 1 reference(s)