Scn8a^m11J
Spontaneous Allele Detail

Summary

• Symbol: Scn8a^m11J
• Name: sodium channel, voltage-gated, type VIII, alpha; mutation 11, Jackson
• MGI ID: MGI:5771986
• Gene: Scn8a Location: Chr15:100767739-100943819 bp, + strand Genetic Position: Chr15, 56.39 cM, cytoband F1
• Alliance: Scn8a^m11J page

Mutation origin

• Strain of Origin: B6.129S7-Itgb2^tm1Bay/J

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutation: Single point mutation
• Mutation details: This spontanoues C-to-T transition in chromosome 15 position 100,959,664 bp, (GRCm38) results in a nonsense mutation from arginine to a termination codon (Cga>Tga) at protein position 226 (p.R226*) (J:222308, J:231578)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn8a Mutation: 99 strains or lines available

References

• Original: J:231578 Harris BS, et al., The spontaneous Scn8a^m11J mutation. MGI Direct Data Submission. 2016
• All: 2 reference(s)