Siim2^MRL/MpJ
QTL Variant Detail

Summary

• QTL variant: Siim2^MRL/MpJ
• Name: stress induced immobility 2; MRL/MpJ
• MGI ID: MGI:5774468
• QTL: Siim2 Location: Chr9:103625682-103625682 bp Genetic Position: Chr9, Syntenic

Variant origin

• Strain of Specimen: MRL/MpJ

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:168320

A variety of 33 inbred strains of mice were phenotyped for stress induced immobility in a Tail Suspension Test(TST). The results of these test with the strains used is recorded in figure 1 of the reference. The variety of responses allowed for discovery of QTL regions associated with these traits. Haplotype analyses of these strains using SNPs with a significance test using A Generalized Family- Wise error rate (gFWER) was used to set -logP values in which 7 or higher was deemed significant. Standardp values were also used. Two loci reached levels of significance.

Siim1 mapped to mouse Chromosome 10 between 94.88 and 95.17 Mbs with a -log p of 8.174 and a p Value of 0.033. Siim1 mapped significantly with rs6196828. Suggested candidates are Socs2, Mrpl42, Ube2n and Nudt4.

Siim2 mapped to mouse Chromosome 9 between 103.44 and 103.74 Mbs with a -log p of 7.324 and a p Value of 0.035. Siim2 mapped significantly with rs29941513. A suggested candidate was Tmem108.

A locus on chromosome 2 (145.75 - 146.97 rs3696377) and a locus on chromosome 9 (92.18 - 92.39 Mb rs33747790) were not significant but were suggestive QTL

References

• Original: J:168320 Miller BH, et al., Phenotypic characterization of a genetically diverse panel of mice for behavioral despair and anxiety. PLoS One. 2010;5(12):e14458
• All: 1 reference(s)