Wwp2^tm1.1Yyiw
Targeted Allele Detail

Summary

• Symbol: Wwp2^tm1.1Yyiw
• Name: WW domain containing E3 ubiquitin protein ligase 2; targeted mutation 1.1, Yan-Yi Wang
• MGI ID: MGI:5774713
• Gene: Wwp2 Location: Chr8:108162997-108285227 bp, + strand Genetic Position: Chr8, 54.15 cM
• Alliance: Wwp2^tm1.1Yyiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228707
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. A second loxP site and neomycin resistance cassette were inserted downstream of exon 3. Cre-mediated recombination removed exon 3. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:228707)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wwp2 Mutation: 373 strains or lines available

References

• Original: J:228707 Yang Y, et al., E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5115-20
• All: 1 reference(s)