Sod2^tm1Kskk
Targeted Allele Detail

Summary

• Symbol: Sod2^tm1Kskk
• Name: superoxide dismutase 2, mitochondrial; targeted mutation 1, Karin Scharffetter-Kochanek
• MGI ID: MGI:5774733
• Synonyms: Sod2^flox
• Gene: Sod2 Location: Chr17:13226726-13237006 bp, + strand Genetic Position: Chr17, 8.75 cM
• Alliance: Sod2^tm1Kskk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98289
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3, which encodes 39 amino acids responsible for homodimerization, tetramer formation and manganese binding, was flanked by loxP sites. A floxed neomycin resistance cassette was inserted upstream of exon 3. (J:98289)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sod2 Mutation: 26 strains or lines available

References

• Original: J:98289 Strassburger M, et al., Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Free Radic Biol Med. 2005 Jun 1;38(11):1458-70
• All: 12 reference(s)