Lsrm1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Lsrm1^C57BL/6J
• Name: locomotor stimulus response to methamphetamine 1; C57BL/6J
• MGI ID: MGI:5774741
• QTL: Lsrm1 Location: unknown Genetic Position: Chr11, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:153539

Sensitivity of the locomotor stimulant response to methamphetamine

(MA) was analysed in an attempt to identify QTL underling the behavior. A/J mice showed less activity then did C57BL/6J mice. CSS-11 is a consomic strain wherein an A/J chromosome 11 hasbeen substituted for a C57BL/6J chromosome on a C57BL/6J background. The main focus of the QTL study was to map loci responsible for activity following treatment with MA, as measured on day 3. Consomic strains CSS-8, -11, and -16 showed less locomotor activity on day 3 following MA administration when compared with C57BL/6J. CSS-11 had the lowest response suggesting the involvement on chromosome 11. The authors genotyped 87 (C57BL/6J CSS-11) F2 mice in a search for the QTL for day 3 activity. For day 3 activity a QTL was observed on mouse Chromosome 11 with a location at 52.4 cM (95% confidence interval = 45-65 cM) and a LOD score of 2.79 (significance level= 2.20). The SNPs listed in the method section which would be included in chromosome 11 are:rs13480888 (16.9 Mb), rs13480921 (25.7 Mb), rs6280308 (32.6 Mb), rs13481015 (48.1 Mb), rs13481044, (57.6 Mb), rs13481117 (79.1 Mb), rs13481170 (95.5 Mb), rs3023315(99.4 Mb), rs13481220 (108.4 Mb) and rs13481256 (118.0 Mb).

References

• Original: J:153539 Bryant CD, et al., A major QTL on chromosome 11 influences psychostimulant and opioid sensitivity in mice. Genes Brain Behav. 2009 Nov;8(8):795-805
• All: 1 reference(s)