Ccr5^tm1(CCR5)Pfi
Targeted Allele Detail

Summary

• Symbol: Ccr5^tm1(CCR5)Pfi
• Name: C-C motif chemokine receptor 5; targeted mutation 1, Pfizer, Ltd
• MGI ID: MGI:5774771
• Synonyms: h-CCR5 ki
• Gene: Ccr5 Location: Chr9:123921557-123934153 bp, + strand Genetic Position: Chr9, 75.05 cM, cytoband F
• Alliance: Ccr5^tm1(CCR5)Pfi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227458
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutation: Intragenic deletion
• Ccr5^tm1(CCR5)Pfi expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CCR5 (1234)

  Ccr5	(MGI:107182)

• The murine Ccr5 is replaced by human CCR5. (J:227458)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccr5 Mutation: 31 strains or lines available

References

• Original: J:227458 Amsellem V, et al., CCR5 as a treatment target in pulmonary arterial hypertension. Circulation. 2014 Sep 9;130(11):880-891
• All: 1 reference(s)