Lmod3^{Tn(pb-Act-RFP)1.1Zhu}
Transposon induced Allele Detail

Summary

• Symbol: Lmod3^{Tn(pb-Act-RFP)1.1Zhu}
• Name: leiomodin 3 (fetal); transposon insertion 1.1, Yuan Zhuang
• MGI ID: MGI:5774799
• Synonyms: Lmod3^PB
• Gene: Lmod3 Location: Chr6:97215495-97229720 bp, - strand Genetic Position: Chr6, 44.92 cM
• Alliance: Lmod3^{Tn(pb-Act-RFP)1.1Zhu} page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Transposon induced (Reporter)
• Mutation: Transposon insertion
• Mutation details: The transposon containing an unspecified hybrid actin promoter driving expression of red fluorescent protein (RFP) flanked by piggyBac-specific left and right terminal sequences was co-injected with a piggyBac-containing transgene to mobilize the transposon. Line 1 contains a transposon inserted downstream of the second coding exon. Western blot analysis confirmed the absence of protein expression in tibialis anterior muscles. (J:123680, J:223382)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmod3 Mutation: 19 strains or lines available

References

• Original: J:223382 Tian L, et al., Leiomodin-3-deficient mice display nemaline myopathy with fast-myofiber atrophy. Dis Model Mech. 2015 Jun;8(6):635-41
• All: 3 reference(s)