Sctr^tm1Brd
Targeted Allele Detail

Summary

• Symbol: Sctr^tm1Brd
• Name: secretin receptor; targeted mutation 1, Allan Bradley
• MGI ID: MGI:5774826
• Synonyms: Sctr^m1Brd
• Gene: Sctr Location: Chr1:119934710-119991269 bp, + strand Genetic Position: Chr1, 52.57 cM
• Alliance: Sctr^tm1Brd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114853
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A beta-galactosidase and neomycin resistance cassette replaced exon 1. RT-PCR confirmed the absence of protein expression in cerebrum, cerebellum, pancreas, heart, liver, kidney, lung, intestine, stomach, spleen and muscle. (J:114853)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sctr Mutation: 27 strains or lines available

References

• Original: J:114853 Nishijima I, et al., Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior. Hum Mol Genet. 2006 Nov 1;15(21):3241-50
• All: 4 reference(s)