Exoc5tm1c(KOMP)Mbp
Targeted Allele Detail
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Symbol: |
Exoc5tm1c(KOMP)Mbp |
Name: |
exocyst complex component 5; targeted mutation 1c, Mouse Biology Program, UC Davis |
MGI ID: |
MGI:5774863 |
Synonyms: |
Sec10FL |
Gene: |
Exoc5 Location: Chr14:49249379-49304124 bp, - strand Genetic Position: Chr14, 25.36 cM
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Alliance: |
Exoc5tm1c(KOMP)Mbp page
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IMPC: |
Exoc5 gene page |
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Mutant Cell Line: |
DEPD00521_3_A02 |
Germline Transmission: |
Earliest citation of germline transmission:
J:226950
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 49273268 of Chromosome 14 upstream of the critical exons 7 through 10 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exons 7 through 10 at position 49275727. The critical exons 7 through 10 are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
(J:226950)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Exoc5 Mutation: |
36 strains or lines available
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Original: |
J:226950 Fogelgren B, et al., Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in Mice Cause Ureteropelvic Junction Obstructions. PLoS One. 2015;10(6):e0129346 |
All: |
9 reference(s) |
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