Ddx3x^tm1.2Lyou
Targeted Allele Detail

Summary

• Symbol: Ddx3x^tm1.2Lyou
• Name: DEAD box helicase 3, X-linked; targeted mutation 1.2, Li-Ru You
• MGI ID: MGI:5774969
• Synonyms: Ddx3x^-
• Gene: Ddx3x Location: ChrX:13147261-13160222 bp, + strand Genetic Position: ChrX, 8.17 cM
• Alliance: Ddx3x^tm1.2Lyou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231798
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted in intron 3 and an frt-PGK-neo-frt-loxP was inserted in exon 17 via homologous recombination. Flp mediated recombination removed the neo cassette and cre mediated recombination removed exons 3-17. (J:231798)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddx3x Mutation: 8 strains or lines available

References

• Original: J:231798 Chen CY, et al., Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis. Hum Mol Genet. 2016 July 15;25(14):2905-2922
• All: 1 reference(s)