Dvs2^DBA/2
QTL Variant Detail

Summary

• QTL variant: Dvs2^DBA/2
• Name: dorsoventral vaginal septum 2; DBA/2
• MGI ID: MGI:5775054
• Synonyms: Dvs2^{B10.BR-H2 H2-T18a/SgSnJ>}
• QTL: Dvs2 Location: unknown Genetic Position: Chr17, Syntenic

Variant origin

• Strain of Specimen: DBA/2

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103481

C57BL/10 and the B10 H2 congenic strains B10.A, B10.A(1R), B10.A(2R), B10.A(5R), B10.A(15R) and B10.A(18R) were used to map loci influencing the frequency of vitamin A induced dorsoventral vaginal septum (DVS). Female animals were examined at 6 weeks of age for the presence of DVS. The B10.A(5R) congenic exhibits this highest incidence of DVS out of all the strain studied. Adding vitamin A to the diet did not increase DVS incidence in B10.A, B10.A(1R), B10.A(5R), B10.A(15R) and B10.A(18R).

Two loci named Dvs1 and Dvs2 mapped to the H2 locus on mouse Chromosome 17. Dvs1 is proximal to H2-Ea (18.7 cM) while Dvs2 is believed to be located between Aecp (19.5 cM) and Dxcp2 (18.975 cM). Dvs1 and Dvs2 may interact to influence the DVS phenotype.

References

• Original: J:103481 Tyan ML, Effects of H-2 and dietary vitamin A on the frequency of dorsoventral vaginal septum. Proc Soc Exp Biol Med. 1993 Jun;203(2):175-8
• All: 1 reference(s)