Zbp1tm1.1Jreh
Targeted Allele Detail
|
Symbol: |
Zbp1tm1.1Jreh |
Name: |
Z-DNA binding protein 1; targeted mutation 1.1, Jan Rehwinkel |
MGI ID: |
MGI:5775152 |
Synonyms: |
Zbp1Zalpah1alpha2, ZBP1-Zalpha1alpha2 mut |
Gene: |
Zbp1 Location: Chr2:173048405-173060715 bp, - strand Genetic Position: Chr2, 95.83 cM, cytoband H3
|
Alliance: |
Zbp1tm1.1Jreh page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:252669
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
C57BL/6N
|
|
Allele Type: |
|
Targeted (Not Specified) |
Mutations: |
|
Insertion, Nucleotide substitutions
|
|
|
Mutation details: The targeting construct introduced several nucleotide substitutions (N46A [AAT to GCT] and Y50A [TAC to GCC] in exon 2 and N122A [AAC to GCC] and Y126A [TAT to GCT] in exon 3), that results in the amino acid substitutions of alanine for asparagine and tyrosine at positions 122 and 126 (N122A/Y126A). The final allele lacks a self-deleting neomycin resistance cassette.
(J:252669)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Zbp1 Mutation: |
29 strains or lines available
|
|
Original: |
J:252669 Maelfait J, et al., Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis. EMBO J. 2017 Sep 1;36(17):2529-2543 |
All: |
3 reference(s) |
|