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Zbp1tm1.1Jreh
Targeted Allele Detail
Summary
Symbol: Zbp1tm1.1Jreh
Name: Z-DNA binding protein 1; targeted mutation 1.1, Jan Rehwinkel
MGI ID: MGI:5775152
Synonyms: Zbp1Zalpah1alpha2, ZBP1-Zalpha1alpha2 mut
Gene: Zbp1  Location: Chr2:173048405-173060715 bp, - strand  Genetic Position: Chr2, 95.83 cM, cytoband H3
Alliance: Zbp1tm1.1Jreh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:252669
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsThe targeting construct introduced several nucleotide substitutions (N46A [AAT to GCT] and Y50A [TAC to GCC] in exon 2 and N122A [AAC to GCC] and Y126A [TAT to GCT] in exon 3), that results in the amino acid substitutions of alanine for asparagine and tyrosine at positions 122 and 126 (N122A/Y126A). The final allele lacks a self-deleting neomycin resistance cassette. (J:252669)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zbp1 Mutation:  29 strains or lines available
References
Original:  J:252669 Maelfait J, et al., Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis. EMBO J. 2017 Sep 1;36(17):2529-2543
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory