Aplnr^tm1.1Path
Targeted Allele Detail

Summary

• Symbol: Aplnr^tm1.1Path
• Name: apelin receptor; targeted mutation 1.1, Patricia A Thistlethwaite
• MGI ID: MGI:5775395
• Synonyms: Aplnr^-:nlacZ
• Gene: Aplnr Location: Chr2:84966704-84970267 bp, + strand Genetic Position: Chr2, 49.45 cM, cytoband E1
• Alliance: Aplnr^tm1.1Path page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227456
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two loxP sites were inserted into the single exon flanking the coding region (base pairs 274-1407, total of 1134 bp) and nuclear lacZ following the second loxP site. The floxed exon was removed via cre-mediated recombination. (J:227456)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aplnr Mutation: 30 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Pulmonary Venoocclusive Disease J:227456.

References

• Original: J:227456 Lathen C, et al., ERG-APLNR axis controls pulmonary venule endothelial proliferation in pulmonary veno-occlusive disease. Circulation. 2014 Sep 30;130(14):1179-91
• All: 1 reference(s)