Cyba^tm1Dgh
Targeted Allele Detail

Summary

• Symbol: Cyba^tm1Dgh
• Name: cytochrome b-245, alpha polypeptide; targeted mutation 1, David G Harrison
• MGI ID: MGI:5775909
• Synonyms: p22^phox/flox
• Gene: Cyba Location: Chr8:123151515-123159669 bp, - strand Genetic Position: Chr8, 71.04 cM, cytoband E1
• Alliance: Cyba^tm1Dgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231269
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was inserted 7.1 kb upstream of the transcription start site. An additional loxP site was inserted in intron 1. (J:231269)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyba Mutation: 18 strains or lines available

References

• Original: J:231269 Lob HE, et al., Role of the NADPH oxidases in the subfornical organ in angiotensin II-induced hypertension. Hypertension. 2013 Feb;61(2):382-7
• All: 3 reference(s)