Atf3^tm1.2Kitab
Targeted Allele Detail

Summary

• Symbol: Atf3^tm1.2Kitab
• Name: activating transcription factor 3; targeted mutation 1.2, Shigetaka Kitajima
• MGI ID: MGI:5775935
• Synonyms: Atf3-flox
• Gene: Atf3 Location: Chr1:190902493-190915530 bp, - strand Genetic Position: Chr1, 96.28 cM, cytoband H6
• Alliance: Atf3^tm1.2Kitab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231262
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neomycin resistance cassette was introduced downstream of exon 2. Cre-mediated recombination removed the selection cassette and left exon 2 floxed. (J:231262)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atf3 Mutation: 21 strains or lines available

References

• Original: J:231262 Lee YS, et al., Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice. Diabetologia. 2013 Jun;56(6):1383-93
• All: 3 reference(s)