Chd4^tm1.2Bh
Targeted Allele Detail

Summary

• Symbol: Chd4^tm1.2Bh
• Name: chromodomain helicase DNA binding protein 4; targeted mutation 1.2, Brian Hendrich
• MGI ID: MGI:5775976
• Synonyms: Chd4^delta, Chd4^tm1.2Bhlab
• Gene: Chd4 Location: Chr6:125073144-125107554 bp, + strand Genetic Position: Chr6, 59.28 cM
• Alliance: Chd4^tm1.2Bh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224146
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 13. A floxed hygromycin resistance cassette was inserted downstream of exon 22. Cre-mediated recombination removed the selection cassette and exons 13 through 21. (J:224146)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chd4 Mutation: 58 strains or lines available

References

• Original: J:224146 O'Shaughnessy-Kirwan A, et al., Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification. Development. 2015 Aug 1;142(15):2586-97
• All: 1 reference(s)