Mapttm2.1(FUS)Neas
Targeted Allele Detail
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Symbol: |
Mapttm2.1(FUS)Neas |
Name: |
microtubule-associated protein tau; targeted mutation 2.1, Neil A Shneider |
MGI ID: |
MGI:5776230 |
Synonyms: |
tauONhFUSR521C |
Gene: |
Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
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Alliance: |
Mapttm2.1(FUS)Neas page
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Germline Transmission: |
Earliest citation of germline transmission:
J:232167
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
Mutations: |
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Insertion, Intragenic deletion
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Mapttm2.1(FUS)Neas expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
FUS (2521) |
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Myc-tagged; R521C mutation |
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Mutation details: A floxed STOP cassette and a modified human cDNA in which nucleotide substitutions resulted in the amino acid substitution of cysteine for arginine at position 521 (R521C) with a myc-tag replaced the 3' portion of exon 2. Cre-mediated recombination removed the stop cassette and allowed for expression of the human sequence.
(J:232167)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mapt Mutation: |
430 strains or lines available
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Original: |
J:232167 Sharma A, et al., ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function. Nat Commun. 2016;7:10465 |
All: |
1 reference(s) |
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