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Mapttm2.1(FUS)Neas
Targeted Allele Detail
Summary
Symbol: Mapttm2.1(FUS)Neas
Name: microtubule-associated protein tau; targeted mutation 2.1, Neil A Shneider
MGI ID: MGI:5776230
Synonyms: tauONhFUSR521C
Gene: Mapt  Location: Chr11:104122216-104222916 bp, + strand  Genetic Position: Chr11, 67.79 cM, cytoband E1
Alliance: Mapttm2.1(FUS)Neas page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:232167
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Mapttm2.1(FUS)Neas expresses 1 gene
 
Mutation detailsA floxed STOP cassette and a modified human cDNA in which nucleotide substitutions resulted in the amino acid substitution of cysteine for arginine at position 521 (R521C) with a myc-tag replaced the 3' portion of exon 2. Cre-mediated recombination removed the stop cassette and allowed for expression of the human sequence. (J:232167)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapt Mutation:  430 strains or lines available
References
Original:  J:232167 Sharma A, et al., ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function. Nat Commun. 2016;7:10465
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory