Mapt^tm3(FUS)Neas
Targeted Allele Detail

Summary

• Symbol: Mapt^tm3(FUS)Neas
• Name: microtubule-associated protein tau; targeted mutation 3, Neil A Shneider
• MGI ID: MGI:5776261
• Synonyms: tau^OFFhFUS^P525L
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^tm3(FUS)Neas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232167
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mapt^tm3(FUS)Neas expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FUS (2521)

  Fus	(MGI:1353633)

  Myc-tagged; P525L mutation

• Mutation details: A floxed STOP cassette and a modified human cDNA in which nucleotide substitutions resulted in the amino acid substitution of leucine for proline at position 525 (P525L) with a myc-tag replaced the 3' portion of exon 2. Cre-mediated recombination is required to remove the stop cassette and allow for expression of the human sequence. (J:232167)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 430 strains or lines available

References

• Original: J:232167 Sharma A, et al., ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function. Nat Commun. 2016;7:10465
• All: 1 reference(s)