Gsdmd^em1Fcw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gsdmd^em1Fcw
• Name: gasdermin D; endonuclease-mediated mutation 1, Fengchao Wang
• MGI ID: MGI:5776359
• Gene: Gsdmd Location: Chr15:75734176-75739257 bp, + strand Genetic Position: Chr15, 35.0 cM, cytoband D3-E1
• Alliance: Gsdmd^em1Fcw page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated frameshift mutations in the gene. Founder line F1-1 contains an 8 bp (Gsdmd^em1Fcw) deletion and a 1bp insertion (Gsdmd^em2Fcw). (J:226781)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsdmd Mutation: 32 strains or lines available

References

• Original: J:226781 Shi J, et al., Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015 Oct 29;526(7575):660-5
• All: 8 reference(s)