Gsdmd^em3Fcw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gsdmd^em3Fcw
• Name: gasdermin D; endonuclease-mediated mutation 3, Fengchao Wang
• MGI ID: MGI:5776362
• Gene: Gsdmd Location: Chr15:75734176-75739257 bp, + strand Genetic Position: Chr15, 35.0 cM, cytoband D3-E1
• Alliance: Gsdmd^em3Fcw page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated frameshift mutations in this gene. Founder line F1-2 contains a 28 bp deletion. (J:226781)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsdmd Mutation: 32 strains or lines available

References

• Original: J:226781 Shi J, et al., Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015 Oct 29;526(7575):660-5
• All: 1 reference(s)