Snhl1^ISS/IbgTejJ
QTL Variant Detail

Summary

• QTL variant: Snhl1^ISS/IbgTejJ
• Name: sensorineural hearing loss 1; ISS/IbgTejJ
• MGI ID: MGI:5776384
• QTL: Snhl1 Location: unknown Genetic Position: Chr10, Syntenic

Variant origin

• Strain of Specimen: ISS/IbgTejJ

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:163117

Linkage analysis was performed on a mapping population of 252 male and female (ILS x ISS) RI mice (LXS, 63 strains, 4 mice/strain) to identify one genomic locus related to sensorineural hearing loss. Mice were genotyped at 11,000 SNP markers.

QTL Snhl1 maps to 54.0 - 60.0 Mb on Chromosome 10 with a peak LOD score of 15.8. ISS-derived alleles are reported to be associated with the sensorineural hearing loss phenotype. Protein-coding gene Cdh23 is suggested as the most likely candidate gene.

References

• Original: J:163117 Noben-Trauth K, et al., Phenotype and genetics of progressive sensorineural hearing loss (Snhl1) in the LXS set of recombinant inbred strains of mice. PLoS One. 2010;5(7):e11459
• All: 1 reference(s)