Lfdr1^ILS/IbgTejJ
QTL Variant Detail

Summary

• QTL variant: Lfdr1^ILS/IbgTejJ
• Name: longevity and fertility response to dietary restriction, QTL 1; ILS/IbgTejJ
• MGI ID: MGI:5776398
• QTL: Lfdr1 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: ILS/IbgTejJ

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:164267

Linkage analysis was performed on a mapping population of ~450 female mice from 42 ILSXISS strains to identify genomic loci related to the effects of dietary restriction. Mice were genotyped at 310 microsatellite markers.

QTL Fedr1 (Fuel efficiency response to dietary restriction, QTL 1) maps to 104 - 122 Mb (rs38696814 - rs33502657) on Chromosome 9 (peak LOD score not given). The ILS allele is associated with increased lifespan and fertility. The protein-coding gene Ppara is suggested as a potential candidate gene.

QTL Lfdr1 (longevity and fertility response to dietary restriction, QTL 1) maps to 93 - 120 Mb (rs37034473 - rs32606941) on Chromosome 7 (peak marker D7Mit351). ILS allele at this locus was associated with a positive effect on both longevity and fertility. The protein-coding gene Cck is noted as a potential candidate gene.

QTL Fedr2 was identified as a suggestive locus in the ILSXISS mapping panel. To confirm the locus, the authors compared the body weights of five ISS.ILS-Lore5^ILS/TejJ congenic mice with that of five ISS/IbgTejJ controls. The results suggest that the congenics carry a locus from the ILS/IbgTejJ strain that confers increased ability to maintain body weight under dietary restriction. The authors call this locus Fedr2. The protein-coding gene Cckbr is listed as a potential candidate gene.

References

• Original: J:164267 Rikke BA, et al., Genetic dissection of dietary restriction in mice supports the metabolic efficiency model of life extension. Exp Gerontol. 2010 Sep;45(9):691-701
• All: 1 reference(s)