Sprr3^tm1.1Ppy
Targeted Allele Detail

Summary

• Symbol: Sprr3^tm1.1Ppy
• Name: small proline-rich protein 3; targeted mutation 1.1, Pampee P Young
• MGI ID: MGI:5776399
• Gene: Sprr3 Location: Chr3:92363809-92366027 bp, - strand Genetic Position: Chr3, 40.14 cM
• Alliance: Sprr3^tm1.1Ppy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230470
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv or C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was replaced with an FRT- and loxP-flanked neomycin resistance cassette. Flp-mediated recmbination removed the selection cassette. Western blot analysis confirmed the absence of protein expression in the forestomach. (J:230470)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sprr3 Mutation: 16 strains or lines available

Notes

The targeting vector was introduced into "a hybrid 129SvEv and C57Bl/6J (129/C57) ES cell line." (J:230470)

References

• Original: J:230470 Segedy AK, et al., Identification of small proline-rich repeat protein 3 as a novel atheroprotective factor that promotes adaptive Akt signaling in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2527-36
• All: 3 reference(s)