Sorbs2^tm1.2Gfng
Targeted Allele Detail

Summary

• Symbol: Sorbs2^tm1.2Gfng
• Name: sorbin and SH3 domain containing 2; targeted mutation 1.2, Guoping Feng
• MGI ID: MGI:5776502
• Synonyms: Sorbs2 KO
• Gene: Sorbs2 Location: Chr8:45960825-46280943 bp, + strand Genetic Position: Chr8, 25.44 cM
• Alliance: Sorbs2^tm1.2Gfng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231609
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting vector was designed with a loxP::frt-SV40 promoter-Neo-pA-frt cassette 389 bp upstream of exon 12, and a loxP site 676 bp downstream of exon 12. Cre-mediated recombination removed exon 12. Western blot analysis of heart and brain tissues confirmed that no protein was expressed in mutant mice. (J:231609)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sorbs2 Mutation: 80 strains or lines available

References

• Original: J:231609 Zhang Q, et al., Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice. J Neurosci. 2016 Feb 17;36(7):2247-60
• All: 2 reference(s)