Gpr4^tm1Mglg
Targeted Allele Detail

Summary

• Symbol: Gpr4^tm1Mglg
• Name: G protein-coupled receptor 4; targeted mutation 1, Marie-Gabrielle Ludwig
• MGI ID: MGI:5776512
• Gene: Gpr4 Location: Chr7:18946463-18958099 bp, + strand Genetic Position: Chr7, 9.46 cM
• Alliance: Gpr4^tm1Mglg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232324
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the coding sequence. RT-PCR confirmed the absence of transcript expression in lung endothelial cells. (J:232324)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr4 Mutation: 19 strains or lines available

References

• Original: J:232324 Wyder L, et al., Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor. Angiogenesis. 2011 Dec;14(4):533-44
• All: 3 reference(s)