Gje1^{tm1b(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Gje1^{tm1b(EUCOMM)Hmgu}
• Name: gap junction protein, epsilon 1; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:5776523
• Synonyms: Cx23-null
• Gene: Gje1 Location: Chr10:14591367-14593958 bp, - strand Genetic Position: Chr10, 5.5 cM, cytoband A2
• Alliance: Gje1^{tm1b(EUCOMM)Hmgu} page
• IMPC: Gje1 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231436
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated excision of the parental Gje^{tm1a(EUCOMM)Hmgu} allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:231436)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gje1 Mutation: 24 strains or lines available

References

• Original: J:231436 Berthoud VM, et al., Connexin23 deletion does not affect lens transparency. Exp Eye Res. 2016 Mar 31;146:283-288
• All: 1 reference(s)